Dietary Glycomacropeptide Increases Fat‐Free Mass, Bone Mineral Content and Fatty Acid Oxidation Compared With Casein In Female Mice

Differential Effects of Dietary Fat Content and Protein Source on Bone Phenotype and Fatty Acid Oxidation in Female C57Bl/6 Mice

BACKGROUND Glycomacropeptide (GMP) is a 64-amino acid glycophosphopeptide released from κ-casein during cheesemaking that promotes satiety, reduces body fat, increases bone mass and infers prebiotic and anti-inflammatory effects. The impact of adiposity and gender on bone health is unclear. OBJECTIVE To determine how feeding female mice diets providing 60% Fat Kcal (high-fat) or 13% Fat Kcal ...

Dietary Casein on Bone and Mineral Metabolism

Long-term administration of olanzapine induces adiposity and increases hepatic fatty acid desaturation protein in female C57BL/6J mice

Objective(s): Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic effects of chronic olanzapine exposure. In addition, we investigated the hepatic fatty acid effects of olanzapine in female C57BL/6J mice fed a normal diet.Materials and Methods: Female C57BL/6J mice ora...

Follicle-stimulating hormone increases bone mass in female mice.

Elevated follicle-stimulating hormone (FSH) activity is proposed to directly cause bone loss independent of estradiol deficiency in aging women. Using transgenic female mice expressing human FSH (TgFSH), we now reveal that TgFSH dose-dependently increased bone mass, markedly elevating tibial and vertebral trabecular bone volume. Furthermore, TgFSH stimulated a striking accrual of bone mass in h...

Relationship of Weight and Body Mass Index with Femur and Lumbar Vertebrae Bone Mineral Density and Content in Premenopausal Women

Purpose: Given that weight and body mass index (BMI) are considered as modifiable factors in osteoporosis, the present study aimed to examine the relationship of weight and BMI with bone mineral density (BMD) and bone mineral content (BMC) at the femur and lumbar vertebrae in perimenopausal women. Methods: In this descriptive-correlational study, we measured the bone density of the femur and...